Is the interaction between ticlopidine and cyclosporin dose related? Report of three cases

Tarik Sqalli Houssaïni, Asmaâ Laboudi, Hakima Rhou, Fatima Ezzaïtouni, Loubna Benamar, Naïma Ouzeddoun, Rabea Bayahia

Abstract


Ticlopidine is an effective anti-platelet agent used for prevention of thrombosis. It was reported that treatment with ticlopidine at the dose of 250 mg daily in kidney transplant patients caused significant reduction of cyclosporin A (CsA) blood levels. In heart transplant patients treated with higher doses of ticlopidine 500 mg daily, it was found to cause significant decrease of cyclosporin concentration but not in those treated with only 250 mg daily. It was thought that ticlopidine interacts with cyclosporin metabolism at cytochrome P450.

(Published: 1 July 2010)

Citation: Libyan J Med 2010, 5: 5334 - DOI: 10.3402/ljm.v5i0.5334

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Libyan Journal of Medicine eISSN 1819-6357, ISSN 1993-2820

This journal is published under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License. Responsible editor: Omran Bakoush